Are people who participate in cultural activities more satisfied with life?

The influence of various aspects of life on wellbeing has been extensively researched. However, despite little empirical evidence, participation in leisure activities has been assumed to increase subjective wellbeing. Leisure is important because it is more under personal control than other sources of life satisfaction. This study asked whether people who participate in cultural leisure activities have higher life satisfaction than people who do not, if different types of leisure have the same influence on life satisfaction and if satisfaction is dependent on the frequency of participation or the number of activities undertaken. It used data from UKHLS Survey to establish associations between type, number and frequency of participation in leisure activities and life satisfaction. Results showed an independent and positive association of participation in sport, heritage and active-creative leisure activities and life satisfaction but not for participation in popular entertainment, theatre hobbies and museum/galleries. The association of reading hobbies and sedentary-creative activities and life satisfaction was negative. High life satisfaction was associated with engaging in a number of different activities rather than the frequency of participation in each of them. The results have implications for policy makers and leisure services providers, in particular those associated with heritage recreation. Subjective wellbeing measures, such as life satisfaction, and not economic measures alone should be considered in the evaluation of services. The promotion of leisure activities which are active and promote social interaction should be considered in programmes aimed at improving the quality of life

The Dynamics of D-3-brane Dyons and Toric Hyper-K\"ahler manifolds

We find the dyonic worldvolume solitons due to parallel (p,q) strings ending on a D-3-brane. These solutions preserve 1/4 of bulk supersymmetry. Then we investigate the scattering of well-separated dyons and find that their moduli space is a toric hyper-K\"ahler manifold. In addition, we present the worldvolume solitons of the D-3-brane which are related by duality to the M-theory configuration of two orthogonal membranes ending on a M-5-brane. We show that these solitons preserve 1/8 of supersymmetry and compute their effective action.Comment: 25 pages, phyzz

A Photonic Topological Mode Bound to a Vortex

Topological photonics sheds light on some of the surprising phenomena seen in condensed matter physics that arise with the appearance of topological invariants. Optical waveguides provide a well-controlled platform to investigate effects that relate to different topological phases of matter, providing insight into phenomena such as topological insulators and superconductors by direct simulation of the states that are protected by the topology of the system. Here, we observe a mode associated with a topological defect in the bulk of a 2D photonic material by introducing a vortex distortion to an hexagonal lattice and analogous to graphene. These observations are made possible by advances in our experimental methods. We were able to manufacture uniform large two-dimensional photonic crystal structures, containing thousands of identical waveguides arranged in two dimensions, and we developed a new method to excite multiples of these waveguides with a well-defined light field. This allows us to probe the detailed spatial features of topological defect modes for the first time. The observed modes lie mid-gap at zero energy and are closely related to Majorana bound states in superconducting vortices. This is the first experimental demonstration of a mode that is a solution to the Dirac equation in the presence of a vortex, as proposed by Jackiw and Rossi

Non-degenerate normal-mode doublets in vibrating flat circular plates

The vibrations of flat circular plates have been studied for hundreds of years, and they are well understood by the scientific community. Unfortunately, when vibrating circular plates are discussed in textbooks, the relationship between pairs of spatially orthogonal vibrational patterns that occur at each of the normal-mode frequencies is often ignored. Usually these orthogonal solutions are presented to the student as being degenerate in frequency; however, in practice the degeneracy of the doublet is often broken and the two spatially orthogonal solutions are separated in frequency. We show theoretically and experimentally that the degeneracy can be broken by a small asymmetry in the plate, and we derive a formula for predicting the magnitude of the frequency-splitting. We have used electronic speckle pattern interferometry to investigate the phenomena of doublet splitting and have confirmed the validity of the theory

Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States.

The extent to which Rhodopsin family G-protein-coupled receptors (GPCRs) form invariant oligomers is contentious. Recent single-molecule fluorescence imaging studies mostly argue against the existence of constitutive receptor dimers and instead suggest that GPCRs only dimerize transiently, if at all. However, whether or not even transient dimers exist is not always clear due to difficulties in unambiguously distinguishing genuine interactions from chance colocalizations, particularly with respect to short-lived events. Previous single-molecule studies have depended critically on calculations of chance colocalization rates and/or comparison with unfixed control proteins whose diffusional behavior may or may not differ from that of the test receptor. Here, we describe a single-molecule imaging assay that 1) utilizes comparisons with well-characterized control proteins, i.e., the monomer CD86 and the homodimer CD28, and 2) relies on cell fixation to limit artifacts arising from differences in the distribution and diffusion of test proteins versus these controls. The improved assay reliably reports the stoichiometry of the Glutamate-family GPCR dimer, γ-amino butyric acid receptor b2, whereas two Rhodopsin-family GPCRs, β2-adrenergic receptor and mCannR2, exhibit colocalization levels comparable to those of CD86 monomers, strengthening the case against invariant GPCR oligomerization.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.bpj.2015.09.00

Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations.

How G protein-coupled receptors (GPCRs) are organized at the cell surface remains highly contentious. Single-molecule (SM) imaging is starting to inform this debate as receptor behavior can now be visualized directly, without the need for interpreting ensemble data. The limited number of SM studies of GPCRs undertaken to date have strongly suggested that dimerization is at most transient, and that most receptors are monomeric at any given time. However, even SM data has its caveats and needs to be interpreted carefully. Here, we discuss the types of SM imaging strategies used to examine GPCR stoichiometry and consider some of these caveats. We also emphasize that attempts to resolve the debate ought to rely on orthogonal approaches to measuring receptor stoichiometry

Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.

The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors. Here, we use a large-scale comparative study to examine the stoichiometric signatures of 60 receptors expressed by a single human cell line. Using bioluminescence resonance energy transfer- and single-molecule microscopy-based assays, we found that a relatively small fraction of Rhodopsin-family GPCRs behaved as dimers and that these receptors otherwise appear to be monomeric. Overall, the analysis predicted that fewer than 20% of ∼700 Rhodopsin-family receptors form dimers. The clustered distribution of the dimers in our sample and a striking correlation between receptor organization and GPCR family size that we also uncover each suggest that receptor stoichiometry might have profoundly influenced GPCR expansion and diversification

Dynamics of Extreme Black Holes and Massive String States

In a recent paper, Duff and Rahmfeld argued that certain massive $N_R=1/2$ states of the four-dimensional heterotic string correspond to extreme black hole solutions. We provide further, dynamical, evidence for this identification by comparing the scattering of these elementary string states with that of the corresponding extreme black holes, in the limit of low velocities.Comment: 18 pages, harvma